SCIENTIFIC LETTER

 

Diminished health and social outcomes among men who have sex with men who use drugs in Zimbabwe

 

 

Munyaradzi Mapingure^I; Innocent Chingombe^I; Tafadzwa Dzinamarira^I; Chesterfield Samba^II; Brian Moyo^III; Owen Mugurungi^III; Godfrey Musuka^IV

^IDepartment of Strategic Information, ICAP at Columbia University, Harare, Zimbabwe
^IIGays and Lesbians Association of ZImbabwe (GALZ), Harare, Zimbabwe
^IIIAIDS and TB Programmes, Ministry of Health and Child Care, Harare, Zimbabwe
^IVInternational Initiative for Impact Evaluation, Harare, Zimbabwe

Correspondence

 

 

Drug and substance use, which is the use of injectable and non-injectable drugs or medicines for pleasure or reasons not recommended by a doctor, is a growing epidemic across the globe, including Zimbabwe. Evidence suggests an upward trend of substance use in the Zimbabwean population.¹ Media reports of youths identified to be in a drunken stupour are widespread, painting an escalating and worrying situation of substance use in the country.^2,3 This can be attributed to increased poverty and dwindling economic opportunities that have left many young people idle and depressed, only to find solace in illicit substance use.⁴ Drug and substance use in Zimbabwe is now rated 8th in the country's top 10 risk factors accounting for disability-adjusted life years lost (DALYs).⁵

The global HIV epidemic among men who have sex with men (MSM) continues to be a significant public health concern worldwide, given the disproportionate burden of infection this group faces.⁶ HIV prevalence in Zimbabwe remains one of the highest globally at 11.6% among the general population⁷ and is even higher at 23.4% among MSM.⁸

Evidence points to high-risk sexual health behaviours and poor health outcomes among drug users. Compared to other persons, HIV-positive people who use drugs were found to experience poorer clinical outcomes, such as antiretroviral therapy (ART) initiation and sustained viral suppression, and higher mortality rates.⁹

Data from our study on HIV and sexually transmissible infection (STI) biobehavioural surveys (BBS) among MSM in Zimbabwe⁷ were used to explore the sexual behaviours and health outcomes among MSM who use drugs in Zimbabwe. Drug use definition was use of injectable or non-injectable drugs or medicine for pleasure or for reasons not recommended by a doctor. We hypothesised that MSM who use drugs have poor health and social outcomes compared to those who do not use drugs. The study was a cross-sectional BBS using respondent-driven sampling. Consenting participants completed a questionnaire on sociodemographic and HIV risk behaviours. They underwent biomarker testing, including rapid testing for HIV, hepatitis B (HBV), and syphilis. HIV-positive patients were tested for CD4, viral load, and recent HIV infection via the rapid test for recent HIV infection. STATA^® statistical package version 17 (StataCorp LLC, College Station, Texas, United States [US]; 2021) was used to compare differences between people who use drugs and those who do not. Chi-square tests were used for categorical variables, while Student's t-test was used for continuous variables. The significance level was set at P = 0.05. Simple proportions were used for descriptive statistics.

The prevalence of drug use was 668/1548 (43%); see Table 1. Unemployment prevalence was higher among those who use drugs (40% vs 36%, P = 0.001), and their earnings were significantly lower ($129.00 vs $209.00, P = 0.017). While only small fractions of either cohort reported being paid with money or goods the first time they had sex with a man, this percentage was higher among those who use drugs compared to those who did not (6.3% vs 2.1%, P = 0.001). The same pattern is shown for exchanging money or goods for sex in their lifetimes. Those who use drugs were more likely to report that they do not use condoms during sex when drunk (35.6% vs 21.8%, P = 0.001). More of those who use drugs have been selling sex for longer (6.7 vs 4.8 years, P = 0.032), and they have a higher percentage misconception that a healthy-looking person cannot have HIV (7.2% vs 4.3%, P = 0.013). Fewer men who use drugs were ever tested for HIV (81.3% vs 88.7%, P = 0.001). Although not statistically significant, a smaller percentage of drug users disclosed their HIV status to anyone. Overall > 90% went for care after testing positive for HIV, and the percentages were similar between the two groups (91.1% vs 94.3%, P = 0.441). A smaller percentage of those who have ever used drugs have ever taken pre-exposure prophylaxis (PrEP) (26.0% vs 32.4, P = 0.099). HIV prevalence was high among MSM who do not use drugs (25.5%) compared to those who do (18.8%). The recency of HIV infection was equally high in MSM not using drugs compared to those using drugs (13.4% vs 5.7%, P = 0.027). CD4 count and percentage of viral load suppression was not statistically different between HIV-positive MSM who use drugs (433 vs 451, P = 0.464) and those who do not (59.4% vs 62.7%, P = 0.545).

People who use drugs are more likely to experience social determinants of poor health, including unemployment or being engaged in lower-paying jobs, which may be interrelated and also, in turn, could exacerbate their substance use patterns.¹⁰

Antiretroviral therapy in people living with HIV improves clinical outcomes and reduces onward transmission risk through viral suppression.¹¹ HIV non-suppression in people living with HIV who use drugs is mainly attributable to sub-optimal ART adherence, which increases HIV incidence.¹² Pre-exposure prophylaxis, which has been shown to reduce HIV transmission, was underutilised in this study sample.¹³

Other adverse health consequences of drug and alcohol use are poorer self-rated health, more physical symptoms, lower life satisfaction and poorer mental health and social functioning.^14,15

In this study, we found diminished health and social outcomes among HIV-positive MSM who use drugs in Zimbabwe. Drug use undoubtedly shapes sexual health risk, as evidenced by higher risk behaviours shown in this study sample among drug users. Drug use is associated with an increased likelihood of engaging in behaviours that elevate the risk of HIV acquisition, which has been reported elsewhere.¹⁶ People who use drugs are disproportionately affected by comorbidities, such as hepatitis C, skin abscesses, and endocarditis, which can lead to adverse HIV clinical outcomes.¹⁷ Several other studies have found that infection with HIV and other STIs is more likely among MSM who use recreational drugs than those who do not.^9,18 We, however, did not find this link in our study.

In conclusion, the world is now faced with a growing epidemic of drug use. People who use drugs engage in risky sexual health behaviours and experience poor health outcomes. This knowledge should be applied toward developing multilevel interventions such as increasing anti-drug use campaigns and strategies to keep men from using. There is a need to establish more detoxification centres to ease drug dependence and treat the disorder. There is an urgent need to address the burden of negative drug use consequences, and this is in synergy with the goals of the World Health Organizaton Special Initiative for Mental Health.¹⁹

 

Acknowledgements

The authors gratefully acknowledge the study team who collected the data for the biobehavioural survey as well as the participants who gave valuable information used in this viewpoint.

Competing interests

The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.

Authors' contributions

G.M. and M.M. conceived the article, carried out the statistical analysis, and wrote the first draft of the article. All authors (M.M., I.C., T.D., C.S., G.M., O.M. and B.M.) contributed to the writing of the article, and read and approved the final viewpoint.

Ethical considerations

Ethical clearance to conduct this study was obtained from the Medical Research Council of Zimbabwe (No. MRC/A/2156) and, Columbia University Human Research Prosecution Office, Institutional Boards (No. IRB-AAAR8950) and the United States Centers for Disease Control and Prevention (CDC) Associate Director of Science (ADS).

Funding information

The study was funded by the US President's Emergency Plan for AIDS Relief through the CDC.

Data availability

Data sharing is not applicable to this article, as no new data were created or analysed in this study.

Disclaimer

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official position of any affiliated agency of the authors.

 

References

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Correspondence:
Munyaradzi Mapingure
pmapingure@yahoo.co.uk

Received: 14 June 2023
Accepted: 08 Aug. 2023
Published: 27 Sept. 2023