Abstract

KUMAR, M. Anil et al. Synthesis and antimicrobial activity of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2 λ⁵-benzoxazaphosphinin-2-thiones. S.Afr.j.chem. (Online) [online]. 2009, vol.62, pp.26-29. ISSN 1996-840X.

Synthesis of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ⁵-benzoxazaphosphinin-2-thiones (3a-j) was accomplished through a two-step process. It involves the prior preparation of 2-chloro-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ⁵-benzoxazaphosphinin-2-thione monochloride (2) and its subsequent reaction with the aminoacid ester hydrochlorides in dry tetrahydrofuran-toluene in the presence of triethylamine at various temperatures. These compounds were characterized by IR, ¹H, ¹³C, ³¹P NMR and mass spectral data.

Keywords : 2-[(6-methyl-2-pyridyl) amino] methylphenol; 1,3,2-benzoxazaphosphinin-2-thione; antimicrobial activity.

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