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South African Journal of Chemistry
On-line version ISSN 1996-840X
Print version ISSN 0379-4350
S.Afr.j.chem. (Online) vol.63 Durban 2010
RESEARCH ARTICLE
Cyclohexenones through addition of ethyl acetoacetate to 3-aryl-1-(thiophen-3-yl)prop-2-en-1-one derivatives
Yakup Budak*; Esra Findik; Mustafa Ceylan
Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, Tokat 60250, Turkey
ABSTRACT
Chalcone derivatives 3a-i: containing a thiophene ring were prepared by the condensation of 1-(thiophen-3-yl)ethanone with aromatic aldehydes in excellent yields. The Michael addition of ethyl acetoacetate 4 to chalcone derivatives 3a-i: resulted in the formation of nine novel ethyl 6-aryl-4-(3-thienyl)cyclohex-3-en-2-one-1-carboxylate derivatives 6a-i
Keywords: Michael addition, ethyl acetoacetate, cyclohexenones, cyclocondensation
Full text available only in PDF format.
Acknowledgements
The authors are indebted to the Department of Chemistry (Gaziosmanpasa University) and the Scientific and Technical Research Council of Turkey (Grant TUBITAK-TBAG (106T103)) for financial support.
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Received 27 April 2009
Revised 4 September 200
Accepted 12 November 2009
* To whom correspondence should be addressed. E-mail: ybudak@gop.edu.tr