Services on Demand
Article
Indicators
Related links
- Cited by Google
- Similars in Google
Share
South African Journal of Bioethics and Law
On-line version ISSN 1999-7639
Abstract
KOTZE, M J et al. Navigating ethical challenges of integrating genomic medicine into clinical practice: Maximising beneficence in precision oncology. SAJBL [online]. 2024, vol.17, n.1, pp.27-34. ISSN 1999-7639. http://dx.doi.org/10.7196/SAJBL.2024.v17i1.2071.
The development of gene expression profiling and next-generation sequencing technologies have steered oncogenomics to the forefront of precision medicine. This created a need for harmonious cooperation between clinicians and researchers to increase access to precision oncology, despite multiple implementation challenges being encountered. The aim is to apply personalised treatment strategies early in cancer management, targeting tumour subtypes and actionable gene variants within the individual's broader clinical risk profile and wellbeing. A knowledge-generating database linked to the South African Medical Research Council's Genomic Centre has been created for the application of personalised medicine, using an integrated service and research approach. Insights gained from patient experiences related to tumour heterogeneity, access to targeted therapies and incidental findings of pathogenic germline variants in tumour DNA, provided practice-changing evidence for the implementation of a cost-minimisation pathology-supported genetic testing strategy. Integrating clinical care with genomic research through data sharing advances personalised medicine and maximises precision oncology benefits.