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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.61 Durban 2008
RESEARCH ARTICLE
Synthesis and antioxidant activity of 3,3'-diselanediylbis (N,N-disubstituted indolizine-1-carboxamide) and derivatives
Chandrashekhar Narajji; Manohar D. Karvekar*; A. Kumar Das
Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, 5 Sarjapur Road, Koramangala, Bangalore, 560 034, India
ABSTRACT
A series of novel diselenides 5a-e were synthesized from α-haloketones, α-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH.). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1-carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from a-picoline and chloroacetic acid by using the Tschischibabin reaction.
Keywords: Antioxidants, diselenides, indolizine, free radical scavenger, 1,1-DPPH
Full text available only in pdf format.
Acknowledgements
The authors sincerely thank the management and staff of Krupanidhi College of Pharmacy for their dedicated collaboration and devotion.
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Received 10 September 2007
Revised 13 March 2008
Accepted 2 April 2008
* To whom correspondence should be addressed. E-mail: ch_pharmacy@rediffmail.com