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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.62 Durban 2009
RESEARCH ARTICLE
Synthesis and biological activity of some Triazolothiadiazoles
Ram J. SinghI; Dharmendra K. SinghII
IQuality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery, Panipat, Haryana-132140, India
IISynthetic Research Laboratory, Department of Chemistry, Faculty of Science, Tilak Dhari Post Graduate College, Jaunpur-222002, India
ABSTRACT
The synthesis of a series of novel 3-pyridyl-6-aryl-s-triazolo[3,4-b]-[1,3,4]-thiadiazoles is described. Fourteen new compounds were synthesized and characterized by spectral and elemental analyses. Some compounds were screened for antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. Compounds containing aryl substituents at position 6 and the 1,2,4-triazole moiety at position 1 or 2 showed reasonable antibacterial activity.
Keywords: 1,2,4-Triazole, thiadiazole, potassium dithiocarbazinate, hydrazine hydrate, antibacterial activity
Full text available only in PDF format.
Acknowledgements
The authors thank the head, Regional Sophisticated Instrument Centre, Central Drug Research Institute, Lucknow, for the analytical and spectral data, Dr T.M. Mohapatra, head of the Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, for the biological screening, and the head of the Chemistry Department of T.D.P.G. College, Jaunpur, for providing laboratory facilities.
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Received 16 October 2008
Revised 23 April 2009
Accepted 24 April 2009
* To whom correspondence should be addressed. E-mail: singhram@iocl.co.in