RESEARCH ARTICLE

 

Cyclohexenones through addition of ethyl acetoacetate to 3-aryl-1-(thiophen-3-yl)prop-2-en-1-one derivatives

 

 

Yakup Budak^*; Esra Findik; Mustafa Ceylan

Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, Tokat 60250, Turkey

 

 

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ABSTRACT

Chalcone derivatives 3a-i: containing a thiophene ring were prepared by the condensation of 1-(thiophen-3-yl)ethanone with aromatic aldehydes in excellent yields. The Michael addition of ethyl acetoacetate 4 to chalcone derivatives 3a-i: resulted in the formation of nine novel ethyl 6-aryl-4-(3-thienyl)cyclohex-3-en-2-one-1-carboxylate derivatives 6a-i

Keywords: Michael addition, ethyl acetoacetate, cyclohexenones, cyclocondensation

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Acknowledgements

The authors are indebted to the Department of Chemistry (Gaziosmanpasa University) and the Scientific and Technical Research Council of Turkey (Grant TUBITAK-TBAG (106T103)) for financial support.

 

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Received 27 April 2009
Revised 4 September 200
Accepted 12 November 2009

 

 

* To whom correspondence should be addressed. E-mail: ybudak@gop.edu.tr