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South African Journal of Chemistry
versión On-line ISSN 1996-840X
versión impresa ISSN 0379-4350
Resumen
KHALAFY, Jabbar et al. Synthesis of some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione derivatives by a one-pot, three-component reaction. S.Afr.j.chem. (Online) [online]. 2017, vol.70, pp.132-136. ISSN 1996-840X. http://dx.doi.org/10.17159/0379-4350/2017/v70a19.
This study reports the reduction of α,β-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl ]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.
Palabras clave : Arylglyoxals; L-cysteine; 1,3-dimethylbarbituric acid; phosphotungstic acid; one-pot; multi-component reaction.
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