Serviços Personalizados
Artigo
Indicadores
Links relacionados
-
Citado por Google
-
Similares em Google
Compartilhar
SAMJ: South African Medical Journal
versão On-line ISSN 2078-5135
versão impressa ISSN 0256-9574
SAMJ, S. Afr. med. j. vol.107 no.7 Pretoria Jul. 2017
http://dx.doi.org/10.7196/samj.2017.v107i7.12551
CORRESPONDENCE
Need for advocacy for maternal immunisation
To the Editor: Even in the current era, many vaccine-preventable diseases, such as measles, polio and hepatitis B, still constitute a significant public health burden despite effective vaccines being available. Various factors contribute to reduced vaccine coverage, such as war-ravaged countries, rural areas with lack of access to healthcare, and the anti-vaxxers, who refuse vaccination, stemming from the disproved measles, mumps, rubella vaccine claims. This leads to disease outbreaks with considerable morbidity and mortality, e.g. measles outbreaks in developing and developed countries.
Besides the advocacy needed for childhood immunisation of vaccine-preventable diseases worldwide, there also exists a need for advocacy with regard to maternal immunisation that healthcare professionals and the public are not well aware of. Maternal immunisation - vaccination of pregnant women - has been shown in trials to protect both the mother and her infant from many vaccine-preventable diseases.[1,2] Transplacental transfer of maternal IgG antibodies provides passive immunity to the infant in the first 6 months of life.[3] As a pregnant healthcare professional seeking vaccination, I was surprised to discover that many obstetricians are unaware of the benefits of maternal immunisation and do not make any recommendations to their pregnant patients.
The South African (SA) National Institute for Communicable Diseases recommends inactivated influenza vaccine for all pregnant women at any stage of pregnancy during the influenza season.[41 Pregnant women are at increased risk of severe or complicated influenza and adverse birth outcomes.[4] A randomised placebo-controlled trial in SA found the influenza vaccine to be safe and effective in both HIV-infected and HIV-uninfected women and their infants.[5] The influenza vaccine is not licensed for infants <6 months of age who are vulnerable to severe or complicated influenza.[4] Maternal influenza immunisation has been shown to protect infants for the first 6 months of life.[5]
Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination of pregnant women has been implemented in the UK and the USA since 2012.[3] Pertussis outbreaks in the USA resulted from the lower duration of protection from the acellular v. the previous whole-cell pertussis vaccines.™ Locally, in KwaZulu-Natal, there were diphtheria outbreaks, and pertussis cases occur nationally.[7,8] The need therefore exists in our setting to protect infants before they develop immunity from the infant vaccine series.
Vaccines in development for maternal immunisation are for the respiratory syncytial virus, which causes bronchiolitis and pneumonia and is a major cause of morbidity and mortality in children, especially infants, and for group B streptococcus, which is a leading cause of invasive infection within the first 3 months of life.[9,10]
There is a misconception among the general public that all vaccines are unsafe during pregnancy; education by healthcare professionals and media communications to dispel false beliefs are required. With the influenza season on the horizon, I urge healthcare professionals to recommend maternal influenza vaccination. Maternal immunisation has the potential to improve maternal and infant health outcomes.
Aabida Khan
Department of Virology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, and National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa. aabida.khan1@gmail.com
References
1. Swamy GK, Beigi RH. Maternal benefits of immunization during pregnancy. Vaccine 2015;33(47):6436-6440. https://doi.org/10.1016/j.vaccine.2015.08.035 [ Links ]
2. Omer SB. Maternal immunization. N Engl J Med 2017;376(13):1256-1267. https://doi.org/10.1056/NEJMra1509044 [ Links ]
3. Chu HY, Englund JA. Maternal immunization. Clin Infect Dis 2014;59(4):560-568. https://doi.org/10.1093/cid/ciu327 [ Links ]
4. National Institute for Communicable Diseases. Healthcare Workers Handbook on Influenza. http://www.nicd.ac.za (accessed 10 May 2017). [ Links ]
5. Madhi SA, Cutland CL, Kuwanda L, et al. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 2014;371(10):918-931. https://doi.org/10.1056/NEJMoa1401480 [ Links ]
6. Gambhir M, Clark TA, Cauchemez S, Tartof SY, Swerdlow DL, Ferguson NM. A change in vaccine efficacy and duration of protection explains recent rises in pertussis incidence in the United States. PLoS Comput Biol 2015;11(4):e1004138. https://doi.org/10.1371/journal.pcbi.1004138 [ Links ]
7. Annamalai M. Diphtheria and the respiratory system: Lessons from 2015 outbreak. S Afr Respir J 2016;22(2):38. https://doi.org/10.7196/SARJ.2016.v22i2.75 [ Links ]
8. Muloiwa R, Dube FS, Nicol MP, Zar HJ, Hussey GD. Incidence and diagnosis of pertussis in South African children hospitalized with lower respiratory tract infection. Pediatr Infect Dis J 2016;35(6):611- 616. https://doi.org/10.1097/INF.0000000000001132 [ Links ]
9. Mazur NI, Martinón-Torres F, Baraldi E, et al. Lower respiratory tract infection caused by respiratory syncytial virus: Current management and new therapeutics. Lancet Respir Med 2015;3(11):888-900. https://doi.org/10.1016/S2213-2600(15)00255-6 [ Links ]
10. Chen VL, Avci FY, Kasper DL. A maternal vaccine against group B streptococcus: Past, present, and future. Vaccine 2013;31:D13-D9. https://doi.org/10.1016/j.vaccine.2012.12.080 [ Links ]