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South African Journal of Chemistry
versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.61 Durban 2008
RESEARCH ARTICLE
Synthesis and antimicrobial activity of new α-aminophosphonic acid esters
Sanapalli S. Reddy; A.U. Ravi Sankar; C. Naga Raju*; V. Koteswara Rao
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India
ABSTRACT
Synthesis of new a-aminophosphonic acid esters (3a-I) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-I) were established by elemental analysis, and IR, 1H, 13C, 31P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.
Keywords: Phenyl glycine ethyl ester, aryl aldehydes, diethyl/dimethylphosphite, antimicrobial activity
Full text available only in pdf format.
Acknowledgements
The authors express their thanks to Prof. C. Devendranath Reddy and Dr C. Suresh Reddy, Department of Chemistry, Sri Venkateswara University, Tirupati, India, for their encouragement and helpful discussion and the Directors, IISc, Bangalore, and CDRI, Lucknow, India, for the analytical and spectral data.
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Received 21 June 2008
Revised 1 August 2008
Accepted 1 October 2008
*To whom correspondence should be addressed. E-mail: naga_raju04@yahoo.co.in