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South African Journal of Chemistry
versão On-line ISSN 1996-840X
versão impressa ISSN 0379-4350
S.Afr.j.chem. (Online) vol.62 Durban 2009
RESEARCH ARTICLE
Synthesis of oxo- and thio-analogues of 2-oxo-2H-chromen-7-yl dimethylcarbamates
Caryl K.A. Janse van Rensburg; Ross S. Robinson
Warren Research Laboratory, School of Chemistry, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa
ABSTRACT
A range of novel 2-oxo-2H-chromen-7-yl dimethylcarbamates was synthesized containing either an oxygen or sulphur atom in the α-position to the carbonyl or thiocarbonyl group of the amide moiety. The synthesis and spectroscopic data of these compounds are reported. Microwave synthesis was essential for the successful synthesis of some of the sulphur-containing carbamates. The synthesized compounds will be used in a subsequent study on the influence of the α -substituent on the amide rotational barrier.
Key words: rotational barrier, thiocarbamates
Full text available only in PDF format.
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Received 26 November 2008
Revised 20 April 2009
Accepted 26 June 2009
* To whom correspondence should be addressed. E-mail: robinsonr@ukzn.ac.za