RESEARCH ARTICLE

 

Synthesis and cytotoxicity screening of some novel benzofuranoyl-pyrazole derivatives against liver and cervix carcinoma cell lines

 

 

Magdy I. El-Zahar; Somaia S. Abd El-Karim; Manal M. Anwar

Therapeutical Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

 

 

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ABSTRACT

A series of new pyrazole, thiazole and thiazolinone derivatives incorporated into benzofuran were synthesized by using 3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-carboxaldehyde as starting material. A total of 41 novel compounds were synthesized. Some of these synthesized compounds were evaluated for cytotoxicity activity against HEPG2 (liver carcinoma cell line) and HELA (cervix carcinoma cell line). The tested compounds (1, 2c, 7c, 8b, 9b, 13b and 14b) showed better activities at low concentration against the commonly used human carcinoma cell lines. A detailed synthesis, spectroscopic data and cytotoxicity screening for the new compounds are described.

Key words: Pyrazole, thiazolinone, benzofuran, benzofuranoyl-pyrazoles, cytotoxic screening, HEPG2, HELA

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Full text available only in PDF format.

 

Acknowledgements

The authors express deepest thanks to Professor Dr Samia Shoman, head of the Pharmacology Unit, National Cancer Institute, Cairo University, for carrying out the anticancer screening, and the staff of the Central Services Laboratory, National Research Centre, Dokki, Cairo, Egypt.

 

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Received 7 April 2009
Revised 28 September 2009
Accepted 26 October 2009

 

 

* To whom correspondence should be addressed. E-mail: melzahar@hotmail.com