RESEARCH ARTICLE

 

Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties

 

 

M. Afzal Azam^*; Bhojraj Suresh; Sandip S. Kalsi; A. Shinesh Antony

Department of Pharmaceutical Chemistry, Jagatguru Sri Sivaratrishawara College of Pharmacy, Ootacamund-643 001, Tamil Nadu, India

 

 

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ABSTRACT

Several 2-mercaptobenzothiazole derivatives containing 1,3,4-oxadiazoles, 1,2,4-triazoles and 1,3,4-thiadiazoles at the second position were synthesized. Some of these synthesized compounds were evaluated for their in vivo analgesic, anti-inflammatory, acute toxicity and ulcerogenic actions. Some of the tested compounds showed significant analgesic and anti-inflammatory activities. Two of the compounds showed significant gastrointestinal protection compared to the standard drug diclofenac sodium. The compounds were also tested for their in vitro antimicrobial activity with most displaying selective activity against the Gram-negative bacteria Pseudomonas aeruginosa. In the present investigation the tested compounds did not possess antifungal activity.

Keywords: 2-Mercaptobenzothiazoles, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, antimicrobial activity, anti-inflammatory activity

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Acknowledgements

The authors are most grateful to His Holiness Jagadguru Sri Sri Sri Shivarathri Deshikendra Mahaswamigalavaru of Sri Suttur Mutt, Mysore, for providing facilities.

 

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Received 3 May 2010
Revised 1 June 2010
Accepted 16 June 2010

 

 

* To whom correspondencshould be addressed. E-mail: afzal9azam@hotmail.com