RESEARCH ARTICLE

 

An efficient and convenient protocol for the synthesis of optically active 1,2,4-triazolo-[3,4-b]-[1,3,4]-thiadiazole, 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives having L-Amino acid moieties

 

 

Naser Foroughifar^{I, *}; Sattar Ebrahimi^II; Akbar Mobinikhaldei^III; Reza Mozafari^III

^IFaculty of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
^IIDepartment of Chemistry, Malayer Branch, Islamic Azad University, Malayer Iran
^IIIDepartment of Chemistry, Arak University, Arak 38156-8-8349, Iran

 

 

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ABSTRACT

A series of novelbis triazolothiadiazole, 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives attached to L-amino acid moieties were synthesized in good yields using a simple and practical method. The structure of all synthesized compounds was confirmed by IR, ¹H NMR, ¹³C NMR spectroscopy and elemental analysis.

Keywords: Amino acid, triazolothiadiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, phosphorus oxychloride, triazole

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Received 28 April 2011
Revised 12 September 2011
Accepted 2 December 2011

 

 

*To whom correspondence should be addressed. E-mail: n_forougifar@yahoo.com