RESEARCH ARTICLE

 

Rapid synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinones using boric acid or sodium dihydrogen phosphate under solvent-free conditions

 

 

Zahed Karimi-Jaberi^*; Leila Zarei

Department of Chemistry, Firoozabad Branch, Islamic Azad University, P.O. Box 74715-117 Firoozabad, Fars, Iran

 

 

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ABSTRACT

Two efficient and convenient methods have been described for synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by one-pot condensation of 2-anthranilamide with aldehydes or ketones in the presence of a catalytic amount of boric acid or sodium dihydrogen phosphate under solvent-free conditions. The attractive features of these processes are short reaction times, easy isolation of products, excellent yields and an environmental friendly procedure

Keywords: Dihydroquinazolinones, boric acid, sodium dihydrogen phosphate, 2-anthranilamide, solvent-free synthesis

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Received 24 November 2011
Revised 18 January 2012
Accepted 7 February 2012

 

 

* To whom correspondence should be addressed. E-mail: z.karimi@iauf.ac.ir