RESEARCH ARTICLE

The facile synthesis of N-aryl isoxazolones as DNA intercalators under solvent-free conditions using microwave irradiation

Ali Reza Molla Ebrahimlo^*

Chemistry Department, Islamic Azad University, Khoy Branch, Khoy, Iran

ABSTRACT

The reaction of chloroheterocycles with some isoxazolones under microwave irradiation and under solvent-free conditions to give the corresponding mono isoxazolinyl derivatives is reported. The main advantages of this method are: (I) elimination of the nitrogen gas (N₂), (II) solvent-free conditions, (III) microwave irradiation, (IV) avoiding the use of silica gel for purification of the products, and (v) higher and shorter reaction times. These compounds have potential applications as DNA intercalators.

Keywords: Isoxazolones, N-aryl isoxazolones, solvent-free, 2-chlorobenzoxazole, 2-chlorobenzothiazole

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Acknowledgement

The author is grateful to the Islamic Azad University, Khoy branch, for its support of this work.

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Received 9 December 2011
Revised 20 February 2012
Accepted 20 March 2012

*E-mail: mollaebrahimilo@yahoo.com