Abstract

RAUF, Abdul; GANGA, Saloni; SHARMA, Shweta  and  ZAHIN, Maryam. A simple, rapid and efficient one-pot protocol for the synthesis of 2-substituted benzothiazole derivatives and their antimicrobial screening. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.63-67. ISSN 1996-840X.

A rapid and efficient condensation reaction of 2-aminothiophenol with various fatty acids in solvent-free conditions with or without microwave irradiation was carried out to afford the corresponding 2-substituted benzothiazole derivatives in good to excellent yields. The structures of the new products were established by elemental analyses, IR, ¹H NMR, ¹³C NMR and mass spectral data. All the title compounds were screened for their antibacterial and antifungal activity. Most of the compounds exhibited good antimicrobial activity.

Keywords : Fatty acids; 2-substituted benzothiazole; 2-aminothiophenol; antimicrobial activity; microwave irradiation.

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