RESEARCH ARTICLE

Synthesis and biological activity of some Triazolothiadiazoles

Ram J. Singh^I; Dharmendra K. Singh^II

^IQuality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery, Panipat, Haryana-132140, India
^IISynthetic Research Laboratory, Department of Chemistry, Faculty of Science, Tilak Dhari Post Graduate College, Jaunpur-222002, India

ABSTRACT

The synthesis of a series of novel 3-pyridyl-6-aryl-s-triazolo[3,4-b]-[1,3,4]-thiadiazoles is described. Fourteen new compounds were synthesized and characterized by spectral and elemental analyses. Some compounds were screened for antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. Compounds containing aryl substituents at position 6 and the 1,2,4-triazole moiety at position 1 or 2 showed reasonable antibacterial activity.

Keywords: 1,2,4-Triazole, thiadiazole, potassium dithiocarbazinate, hydrazine hydrate, antibacterial activity

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Acknowledgements

The authors thank the head, Regional Sophisticated Instrument Centre, Central Drug Research Institute, Lucknow, for the analytical and spectral data, Dr T.M. Mohapatra, head of the Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, for the biological screening, and the head of the Chemistry Department of T.D.P.G. College, Jaunpur, for providing laboratory facilities.

References

1 B. Zeeh and H. Goetz, J. Indian Chem. Soc., 1981, 280, 2923-2926.         [ Links ]

2 A. Gamala and M. Ahmed, J. Indian Chem. Soc., 1997, 74, 624-625.         [ Links ]

3 S.S. Parmar, M. Choudhary, S.K. Choudhary, S. Kumar and H.R. Sapiro, J. Pharm. Sci., 1997, 66, 971-973.         [ Links ]

4 D.K. Singh, R.J. Singh, K.M. Mahadevan, H.M. Vagdevi and VP Vaidha, Indian J. Chem., 2003, 42B, 1931-1932.         [ Links ]

5 K.M. Mahadevan, D.K. Singh and R.J. Singh, Indian J. Heterocycl. Chem., 2003,13, 151-155.         [ Links ]

6 R.J. Singh, J. Purvanchal Acad. Sci., Ser. B, 2006, 12, 21-24.         [ Links ]

7 J.R. Reid and N.D.J. Heindel, J. Heterocycl. Chem., 1976, 13, 925-926.         [ Links ]

8 R. Cruickshank, J.P. Duguid, B.P. Marmoin and H.A. Swam (eds.), The Practice of Medical Microbiology, vol. 3, 12th edn., Churchill Livingstone, London, 1975, p. 544.         [ Links ]

9 L.J. Bradshaw (ed.), A Textbook of Microbiology, W.B. Saunders, Philadelphia, PA, USA, 1979, pp. 1151-1162.         [ Links ]

10 S. Rich and J.G. Horsfall, Phytopathology, 1952, 42, 477-480.         [ Links ]

11 H.W. Seeley and P.J. Vandenmark, Microbes in Action: a Laboratory Manual of Microbiology, D.B.Taraporevala & Sons, Bombay, India, 1975, pp. 55-88.         [ Links ]

12 J.B. Elene and M.F. Sydney, Methods for Testing Antimicrobial Effectiveness, Diagnostic Microbiology, Mosey Company, Cincinnati, OH, USA, 1990, pp. 171-194.         [ Links ]

13 S. Ersan, S. Nacak and R. Berken, Farmaco, 1998, 53, 773-776.         [ Links ]

Received 16 October 2008
Revised 23 April 2009
Accepted 24 April 2009

* To whom correspondence should be addressed. E-mail: singhram@iocl.co.in