Abstract

SIDDIQUI, Naqui-Jahan; IDREES, Mohammad; KHATI, N.T.  and  DHONDE, M. G.. Synthesis and Antimicrobial Activities of Some New Pyrazoles, Oxadiazoles and Isoxazole Bearing Benzofuran Moiety. S.Afr.j.chem. (Online) [online]. 2013, vol.66, pp.248-253. ISSN 1996-840X.

The synthesis of novel derivatives of pyrazole-3-carboxylate (3-5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1)is reported. Synthesis of substituted 1,3,4-oxadiazoles (7-11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting from the 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, ¹H NMR, ¹³C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gram-negative bacteria and a fungus.

Keywords : 2,4-Dioxobutanoate; isoxazole; pyrazoles; pyrazole-3-carbohydrazide; 1,3,4-oxadiazoles.

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