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South African Dental Journal

On-line version ISSN 0375-1562
Print version ISSN 0011-8516


PATEL, E; CHOONARA, YE  and  PILLAY, V. Dental biomaterials: challenges in the translation from lab to patient. S. Afr. dent. j. [online]. 2020, vol.75, n.1, pp.16-28. ISSN 0375-1562.

Biomaterials are essential components of modern medicine. Dental biomaterials include any material or device used within the oral cavity for the diagnosis and treatment of oral conditions, diseases, and disorders. Whilst the literature remains abuzz with innovative and diverse technologies, an apparent disconnect is evident in the follow-through, affecting the impact on current clinical treatment regimens. This review will explore the product development process from concept to clinical application, in conjunction with the commercial aspects that affect clinical translation. Though serving the purpose of a roadmap for novice inventors, the primary intention of the paper is to focus on some of the challenges cited in the literature and to highlight factors that delay or, in due course, actually prevent clinical translation of even the grandest inventions. Clinicians should also be alert to the complexities affecting the arrival in their surgeries of new products and technologies, The ultimate aim is to assist in the decision-making of researchers when they may be initiating novel advances in oral-related therapies, by ensuring they are cognisant of past errors and limitations, whilst at the same time recognizing present hurdles.

Keywords : Biomaterials; challenges; clinical translation; dental bio-material challenges; biomaterial commercial challenges.

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