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South African Journal of Chemistry

On-line version ISSN 1996-840X
Print version ISSN 0379-4350

S.Afr.j.chem. (Online) vol.63  Durban  2010




1,5-bis (2-hydroxyphenyl)pent-1,4-diene-3-one: A lead compound for the development of broad-spectrum antibacterial agents



Archna RaniI, *; Sapna JainI; Rita KumarII; Anil KumarII

IDepartment of Applied Chemistry, Delhi Technological University, Bawana Road, Delhi 110042, India
IIEnvironmental Biotechnology Division, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India




A systematic and comparative study has been made starting from a naturally-occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (lc)asalead compound with potential against a panel of pathogenic bacterial strains, Staphylococcus (coagulase negative), Escherichia coli, Pseudomonas aeruginosa, Acenetobacter sp. and Klebsiella pneumoniae. Gentamycine and tetracycline were used as reference drugs. The mode of antibacterial action of 1c was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. In vitro toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.

Keywords: Chalcone, antibacterial agent, MIC, α,β-unsaturated carbonyl compounds



Full text available only in PDF format.



We thank Delhi Technological University, Delhi, for providing the facilities during the studies and Dr A.A. Gupta for his helpful discussions. One of the authors (S.J.) is also grateful to the University Grant Commission for financial support.



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Received 7 December 2009
Revised 21 February 2010
Accepted 31 March 2010



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