SHORT COMMUNICATION

 

An environmentally friendly solvent-free synthesis of 3,4-dihydropyrimidinones using a p-aminobenzene sulfonic acid catalyzed Biginelli reaction

 

 

Ming Shu Wu^{I,II, *}; Ping He^II; Xiang Zhu Zhang^I

^IDepartment of Chemical Engineering, Institute of Anyang Technology, Anyang, 455000, Henan, P.R. China
^IIDepartment of Chemistry, Hainan Normal University, Haikou 571158, Hainan, P.R. China

 

 

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ABSTRACT

Anhydrous p-aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidi-nones by the cyclocondensation of aldehydes, β-ketoesters and urea/thiourea. Yields obtained are significantly higher than those obtained utilizing classical Biginelli reaction conditions.

Keywords: Anhydrous p-aminobenzene sulphonic acid, 3,4-dihydropyrimidinones, Biginelli reaction

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Received 28 June 2010
Revised 5 August 2010
Accepted19 August 2010

 

 

* To whom correspondence should be addressed. E-mail: wumingshu@126.com