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Journal of the South African Veterinary Association

versão On-line ISSN 2224-9435
versão impressa ISSN 1019-9128

J. S. Afr. Vet. Assoc. vol.79 no.4 Pretoria  2008




Is the current dose of a conventional oxytetracycline formulation adequate for the management of infections in sheep?



M G SnymanI; V NaidooI; C de BruinII; G E SwanI

IDepartment of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
IIBerea Veterinary Clinic, 12 Scherwitz Road, Berea, East London, 5214 South Africa




In the veterinary industry, short-acting or conventional Oxytetracycline formulations are recommended for use once a day for 4 days, at a dose of 10 mg/kg. With the large degree of antimicrobial resistance reported, the efficacy of this dose was assessed using pharmacodynamic modelling. The specific parameters evaluated were based on the time-dependent activity of the tetracycline class of antimicrobials according to the total time above minimal inhibitory concentration (T > MIC) and the ratio of the total exposure in 24 hours, represented by area under the curve (AUC24), to the minimal inhibitory concentration (AUC24:MIC). The current pharmacokinetic study examined whether the prevailing antimicrobial resistance could be overcome by doubling the recommended conventional dose. Using reported MIC data for South Africa and elsewhere, modelling indicated the presence of a large degree of resistance. In general, doubling the dose only overcame resistance of 2 bacterial species in South Africa.

Key words: conventional formulation, oxytetracycline, pharmacodynamic, pharmaco-kinetic, sheep



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Received: July 2008.
Accepted: October 2008



* Author for correspondence. E-mail:

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